or  Wolfram's syndrome  n :  a rare hereditary disorder that is characterized esp. by insulin-dependent diabetes mellitus, diabetes insipidus, optic atrophy, sensorineural deafness, and bladder dysfunction and that is inherited as an autosomal recessive trait
 
Wolfram, D. J. (fl 1938), American physician. Wolfram published a report on four cases of Wolfram syndrome in 1938.
 
 
 
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