n 1  :  a disease of horses, cattle, and sheep caused by chronic poisoning with locoweeds and characterized by motor and sensory nerve damage resulting in peculiarities of gait, impairment of vision, lassitude or extreme excitement, emaciation, and ultimately paralysis and death if not controlled  2  :  any of several intoxications of domestic animals (as selenosis) that are sometimes confused with locoweed poisoning .
 
 
 
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