or Brit  his*ti*di*nae*mia  n :  a recessive autosomal metabolic defect that results in an excess amount of histidine in the blood and urine due to a deficiency of histidase and is characterized by speech defects and mild mental retardation his*ti*di*ne*mic or Brit  his*ti*di*nae*mic  adj 
 
 
 
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