or chiefly Brit  hy*po-oes*tro*gen*ism  n :  a deficiency of estrogen in the body <long-term administration of a gonadotropin-releasing hormone agonist induces and amenorrhea -B. D. Cowan et al>  hy*po*es*tro*gen*ic or chiefly Brit  hy*po-oes*tro*gen*ic  adj 
 
 
 
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